Ansu Fati, Memphis Depay, Eric Garcia, Sergi Roberto, Samuel Umtiti and Clement Lenglet will all sit out the clash between fourth and fifth in the table.
A late winner at Alaves last time out eased Barcelona’s troubles, having suffered early exits in the Copa del Rey and Supercopa de Espana. But they remain outside the Champions League qualification places and are a whopping 15 points off leaders Real Madrid.
Sergino Dest was the last back from international duty but did not feature in the United States’ World Cup qualifier with Honduras, so it remains to be seen if he will feature.
It is also up in the air as to whether Ousmane Dembele will be named in the squad after his January departure failed to come off.
Xavi should have Ronald Araujo and Dani Alves to pick from after they returned to training on Thursday following their international exploits.
Barcelona predicted XI: Ter Stegen; Dest, Pique, Araujo, Alba; De Jong, Busquets, Pedri; Torres, De Jong, Aubameyang.