It was a comfortable progression to the fourth round for the Blues, who beat non-league Chesterfield 5-1 at home at the start of the year.
Even while their Premier League form has been inconsistent, Chelsea have remained impressive in the cups - they have a Carabao Cup final against Liverpool later this month to look forward to. This is the Blues’ first match in nearly two weeks.
Plymouth have been enjoying a strong season in League One, currently sitting just outside of the play-off places. They edged past Birmingham in extra time in the third round.
There have been 19 goals in Plymouth’s last four league matches, and there is every chance of another high-scoring encounter when they face Thomas Tuchel’s well-rested side.
Follow all the action with Standard Sport’s LIVE blog below...
Tuchel open to invention after quiet January
Thomas Tuchel plans to be more versatile with Chelsea’s system after rejecting opportunities to strengthen his squad in January.
The German confirmed the European champions had been offered players last month, as he looked to bring in cover for the injured Ben Chilwell and Reece James.
But a failure to land any long-term targets – or recall Emerson Palmieri from loan at Lyon – saw Kenedy become the only first team addition after the Brazilian returned from a season-long loan at Flamengo.
Standard Sport prediction
Given Chelsea’s almost imperious form in cup competitions under Tuchel, it’s too hard to look past a home win.
Chelsea to win 3-0.
The Bridge is ready for more FA Cup action
Predicted Chelsea XI: Bettinelli; Chalobah, Christensen, Rudiger; Azpilicueta, Kante, Jorginho, Alonso; Ziyech, Lukaku, Hudson-Odoi.
Early team news
Reece James will miss the game for Chelsea, as well as the Club World Cup, after coming down with flu having only just overcome a hamstring injury.
Andreas Christensen (back) and Trevoh Chalobah (hamstring) are back from injury problems but Ruben Loftus-Cheek (knock) is out.
Christian Pulisic and Thiago Silva are set to be unavailable having not yet returned to training after their international exploits in the past week.
How to watch
TV channel: The game will be broadcast on the BBC via their red button service.
Live stream: Both the BBC iPlayer and the BBC Sport website will offer live streams.
Hello and welcome!
The FA Cup fifth-round got underway last night with an upset as Manchester United lost at home to Championship side Middlesbrough.
And today we have another potential banana skin to bring you as Chelsea take on Plymouth at Stamford Bridge.
The Blues rarely fall foul of such a David vs Goliath battle - and you can follow along with all the action with Standard Sport.
Team news is due out in about an hour...